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p-ISSN: 0973-0109 e-ISSN: 2319-6750

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Abstract

Insilico and Invitro analysis of Acorus calamus in support for antibacterial activity

Sri devi.M, Vinothini.K, Sridhar. S and Veronica Shalini*

Advanced BioTech, Volume:12 Issue:06 December 10, 2012
Abstract
The antibacterial and structural properties of the metabolites are well understood with the use of computational tools. In the present study, we have investigated in silico and in vitro methods to improve our ability to predict potential antibacterial activities of traditional plants found in south India.¬† In silico studies were done for the metabolites of the plant Acorus calamus against Bacillus subtilis. The receptors chosen for these were Quorum sensing protein LuxS, Glutamate racemase and FtsZ present in the bacteria. The receptors were selected based on the bacterial life cycle. Docking Studies have become nearly indispensable for the study of macromolecular structures and interactions. In the present study docking-the key to rational drug design was done using PyRx 0.8. The insilico works showed ligands had a good binding action towards receptors and they were proved with substantial antibacterial activity, which showed a positive result.
 
Author Affiliations
 
Sri devi.M, Vinothini.K, Sridhar. S and Veronica Shalini*
Department  of Biotechnology Jeppiaar Engineering College, Chennai, Tamil Nadu, India.
*Corresponding Author E mail : shalinijeyadoss@gmail.com
To cite this article
 
Sri devi.M, Vinothini.K, Sridhar. S and Veronica Shalini* 2012. Insilico and Invitro analysis of Acorus calamus in support for antibacterial activity . Adv Bio Tech:12(06):11-14
 
 
2012 dec_ cover
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